pka inhibitors h89 Search Results


pka inhibitor h-89  (LC Laboratories)
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pka inhibitor h89  (Cayman Chemical)
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pka inhibitor h89  (Biomo Pharma GmbH)
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pka inhibitors h-89, h-88 or h-85  (Seikagaku corporation)
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Pka Inhibitors H 89, H 88 Or H 85, supplied by Seikagaku corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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death associated protein kinase (dapk) inhibitor (di) ‘‘death-associated protein kinase inhibitor (4z)-4-(3-pyridylmethylene)-2-styryl-oxazol-5-one  (Merck KGaA)
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pka inhibitor h-89  (Biolog Inc)
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pka inhibitors h-89  (Biomol GmbH)
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pka inhibitor h89  (Enzo Biochem)
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pka inhibitor h-89  (Beyotime)
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pka inhibitor h89  (Novartis)
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Novartis pka inhibitor h89
(A, B) Western blot from postnatal day 16 (P16) sciatic nerves shows that the levels of Oct6 and Egr2 are increased in Lama 2 −/− and Nrg1III tg // Lama 2 −/− nerves but not when neuregulin 1 type III (Nrg1III) is overexpressed alone. The experiments were repeated at least 3 times on 5 (Oct6) or 4 (Egr2) different animals per genotype. * p < 0.05; ** p = 0.006; *** p < 0.0001 by 1-way ANOVA with Bonferroni multiple comparison test. (C) Sciatic nerve longitudinal sections at P16 from the indicated genotypes were stained for Oct6 or Egr2 (green) and DAPI (blue). (D, E) Quantification of the fraction of positive Oct6 and EGR2 nuclei. Three animals per genotype were analyzed. * p < 0.05; ** p < 0.005; *** p = 0.0007. A, B, D, E statistic by 1-way ANOVA with Bonferroni posthoc test for individual comparisons. (F) Western blot analysis showing dose-dependent induction of Egr2 and Oct6 by protein kinase A <t>(PKA)-selective</t> agonists in primary Schwann cells (SCs) in culture. (G) The inhibition of ErbB2 with PKI166 suppresses 3′-5′-cyclic adenosine monophosphate (cAMP)-induced Grb2-Associated Binder-1 (Gab1) phosphorylation, but not the expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05 by Student t test. (H) PKA inhibition with <t>H89</t> suppresses cAMP-induced expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05, **, p < 0.01 by Student t test). Bar = 100 μm in C. The numerical data used in A-B, D-E, G-H are included in .
Pka Inhibitor H89, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pka inhibitor h-89  (Expresson)
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Expresson pka inhibitor h-89
(A, B) Western blot from postnatal day 16 (P16) sciatic nerves shows that the levels of Oct6 and Egr2 are increased in Lama 2 −/− and Nrg1III tg // Lama 2 −/− nerves but not when neuregulin 1 type III (Nrg1III) is overexpressed alone. The experiments were repeated at least 3 times on 5 (Oct6) or 4 (Egr2) different animals per genotype. * p < 0.05; ** p = 0.006; *** p < 0.0001 by 1-way ANOVA with Bonferroni multiple comparison test. (C) Sciatic nerve longitudinal sections at P16 from the indicated genotypes were stained for Oct6 or Egr2 (green) and DAPI (blue). (D, E) Quantification of the fraction of positive Oct6 and EGR2 nuclei. Three animals per genotype were analyzed. * p < 0.05; ** p < 0.005; *** p = 0.0007. A, B, D, E statistic by 1-way ANOVA with Bonferroni posthoc test for individual comparisons. (F) Western blot analysis showing dose-dependent induction of Egr2 and Oct6 by protein kinase A <t>(PKA)-selective</t> agonists in primary Schwann cells (SCs) in culture. (G) The inhibition of ErbB2 with PKI166 suppresses 3′-5′-cyclic adenosine monophosphate (cAMP)-induced Grb2-Associated Binder-1 (Gab1) phosphorylation, but not the expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05 by Student t test. (H) PKA inhibition with <t>H89</t> suppresses cAMP-induced expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05, **, p < 0.01 by Student t test). Bar = 100 μm in C. The numerical data used in A-B, D-E, G-H are included in .
Pka Inhibitor H 89, supplied by Expresson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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h89 (a pka inhibitor)  (Enzo Biochem)
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Enzo Biochem h89 (a pka inhibitor)
(A, B) Western blot from postnatal day 16 (P16) sciatic nerves shows that the levels of Oct6 and Egr2 are increased in Lama 2 −/− and Nrg1III tg // Lama 2 −/− nerves but not when neuregulin 1 type III (Nrg1III) is overexpressed alone. The experiments were repeated at least 3 times on 5 (Oct6) or 4 (Egr2) different animals per genotype. * p < 0.05; ** p = 0.006; *** p < 0.0001 by 1-way ANOVA with Bonferroni multiple comparison test. (C) Sciatic nerve longitudinal sections at P16 from the indicated genotypes were stained for Oct6 or Egr2 (green) and DAPI (blue). (D, E) Quantification of the fraction of positive Oct6 and EGR2 nuclei. Three animals per genotype were analyzed. * p < 0.05; ** p < 0.005; *** p = 0.0007. A, B, D, E statistic by 1-way ANOVA with Bonferroni posthoc test for individual comparisons. (F) Western blot analysis showing dose-dependent induction of Egr2 and Oct6 by protein kinase A <t>(PKA)-selective</t> agonists in primary Schwann cells (SCs) in culture. (G) The inhibition of ErbB2 with PKI166 suppresses 3′-5′-cyclic adenosine monophosphate (cAMP)-induced Grb2-Associated Binder-1 (Gab1) phosphorylation, but not the expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05 by Student t test. (H) PKA inhibition with <t>H89</t> suppresses cAMP-induced expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05, **, p < 0.01 by Student t test). Bar = 100 μm in C. The numerical data used in A-B, D-E, G-H are included in .
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Image Search Results


(A, B) Western blot from postnatal day 16 (P16) sciatic nerves shows that the levels of Oct6 and Egr2 are increased in Lama 2 −/− and Nrg1III tg // Lama 2 −/− nerves but not when neuregulin 1 type III (Nrg1III) is overexpressed alone. The experiments were repeated at least 3 times on 5 (Oct6) or 4 (Egr2) different animals per genotype. * p < 0.05; ** p = 0.006; *** p < 0.0001 by 1-way ANOVA with Bonferroni multiple comparison test. (C) Sciatic nerve longitudinal sections at P16 from the indicated genotypes were stained for Oct6 or Egr2 (green) and DAPI (blue). (D, E) Quantification of the fraction of positive Oct6 and EGR2 nuclei. Three animals per genotype were analyzed. * p < 0.05; ** p < 0.005; *** p = 0.0007. A, B, D, E statistic by 1-way ANOVA with Bonferroni posthoc test for individual comparisons. (F) Western blot analysis showing dose-dependent induction of Egr2 and Oct6 by protein kinase A (PKA)-selective agonists in primary Schwann cells (SCs) in culture. (G) The inhibition of ErbB2 with PKI166 suppresses 3′-5′-cyclic adenosine monophosphate (cAMP)-induced Grb2-Associated Binder-1 (Gab1) phosphorylation, but not the expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05 by Student t test. (H) PKA inhibition with H89 suppresses cAMP-induced expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05, **, p < 0.01 by Student t test). Bar = 100 μm in C. The numerical data used in A-B, D-E, G-H are included in .

Journal: PLoS Biology

Article Title: Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

doi: 10.1371/journal.pbio.2001408

Figure Lengend Snippet: (A, B) Western blot from postnatal day 16 (P16) sciatic nerves shows that the levels of Oct6 and Egr2 are increased in Lama 2 −/− and Nrg1III tg // Lama 2 −/− nerves but not when neuregulin 1 type III (Nrg1III) is overexpressed alone. The experiments were repeated at least 3 times on 5 (Oct6) or 4 (Egr2) different animals per genotype. * p < 0.05; ** p = 0.006; *** p < 0.0001 by 1-way ANOVA with Bonferroni multiple comparison test. (C) Sciatic nerve longitudinal sections at P16 from the indicated genotypes were stained for Oct6 or Egr2 (green) and DAPI (blue). (D, E) Quantification of the fraction of positive Oct6 and EGR2 nuclei. Three animals per genotype were analyzed. * p < 0.05; ** p < 0.005; *** p = 0.0007. A, B, D, E statistic by 1-way ANOVA with Bonferroni posthoc test for individual comparisons. (F) Western blot analysis showing dose-dependent induction of Egr2 and Oct6 by protein kinase A (PKA)-selective agonists in primary Schwann cells (SCs) in culture. (G) The inhibition of ErbB2 with PKI166 suppresses 3′-5′-cyclic adenosine monophosphate (cAMP)-induced Grb2-Associated Binder-1 (Gab1) phosphorylation, but not the expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05 by Student t test. (H) PKA inhibition with H89 suppresses cAMP-induced expression of Oct6/Egr2 in primary SCs. ( n = 3, *, p < 0.05, **, p < 0.01 by Student t test). Bar = 100 μm in C. The numerical data used in A-B, D-E, G-H are included in .

Article Snippet: PKA inhibitor H89 (Novartis, Basel, Switzerland) and ErbB2 inhibitor PKI166 (Novartis, Basel, Switzerland) were added after 24h of dbcAMP treatment and then left for 2 days in combination with dbcAMP (Figs and ).

Techniques: Western Blot, Comparison, Staining, Inhibition, Phospho-proteomics, Expressing

(A) Schematic representation of the hypothesis that Lm211 inhibits ErbB2/3 and Gab1 downstream of Nrg1III by negatively regulating PKA. (B) The PKA inhibitor H89 dose-dependently suppressed dbcAMP-induced ErbB2 and Gab1 phosphorylation in rat Schwann cells (SCs). dbcAMP was used for 3 days ( n = 3, * p < 0.05; ** p < 0.001 by Student t test). (C) Intermuscular injection of HB9 and KT5720 for 4 days reduced PKA activity, revealed by a decrease in PKA phospho-substrates. (D, E) Similar treatment significantly reduced ErbB2 and Gab1 activation in Nrg1III tg // Lama 2 −/− and, to a lesser extent, in the other genotypes. The experiments were repeated at least 5 (D) or 3 (E) animals per genotype. * p < 0.05, *** p < 0.005, *** p < 0.001 by Student t test. The numerical data used in B, D-E, are included in .

Journal: PLoS Biology

Article Title: Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

doi: 10.1371/journal.pbio.2001408

Figure Lengend Snippet: (A) Schematic representation of the hypothesis that Lm211 inhibits ErbB2/3 and Gab1 downstream of Nrg1III by negatively regulating PKA. (B) The PKA inhibitor H89 dose-dependently suppressed dbcAMP-induced ErbB2 and Gab1 phosphorylation in rat Schwann cells (SCs). dbcAMP was used for 3 days ( n = 3, * p < 0.05; ** p < 0.001 by Student t test). (C) Intermuscular injection of HB9 and KT5720 for 4 days reduced PKA activity, revealed by a decrease in PKA phospho-substrates. (D, E) Similar treatment significantly reduced ErbB2 and Gab1 activation in Nrg1III tg // Lama 2 −/− and, to a lesser extent, in the other genotypes. The experiments were repeated at least 5 (D) or 3 (E) animals per genotype. * p < 0.05, *** p < 0.005, *** p < 0.001 by Student t test. The numerical data used in B, D-E, are included in .

Article Snippet: PKA inhibitor H89 (Novartis, Basel, Switzerland) and ErbB2 inhibitor PKI166 (Novartis, Basel, Switzerland) were added after 24h of dbcAMP treatment and then left for 2 days in combination with dbcAMP (Figs and ).

Techniques: Phospho-proteomics, Injection, Activity Assay, Activation Assay